Proteins can be coupled either covalently or via a specific tag to a sensor surface.
In interaction analysis with a potent binding partner we can roughly predict the binding kinetics using only two concentrations of the analyte (qualitative analysis) or we determine the exact kinetic data (kass, kdiss, KD) using 8-10 different concentrations of the binding partner (quantitative analysis).
Peptide and peptide fragments selected from phage display libaries have been extensively used in studying antigen / antibody interactions and to explore the therapeutic feasibility in drug discovery processes.
Since direct immobilisation of the peptide is not always favorable it becomes necessary to immobilise the protein to the sensor surface for some interaction studies. Biaffin has developed methods to analyze even low response signals of peptides to generate reproducible kinetic data even for this class of compounds.
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