IMMUNOREACTIVITY
Do you want to check your newly designed pharmaceuticals for an immune response? Biacore is a powerful technique for quantitative detection of drug derived antibodies in serum samples. Even low affinity antibodies displaying fast off-rates can reproducibly be detected.
Our service:
- imobilization of the new drug on a chip surface (as the “antigen”)
- appropriate control experiments to detect positive binding signals
- detection of low levels of antibodies in serum samples clearly identified as a specific binding signal despite of the complexity of the protein mixture in serum samples
- subtype classification of bound antibodies identifying them as IgG or IgM antibodies is possible using suitable secondary antibodies in a subsequent sandwich experiment