IMMUNOREACTIVITY

Do you want to check your newly designed pharmaceuticals for an immune response during preclinical studies?
Biacore is a powerful technique for quantitative detection of drug derived antibodies in serum samples.

imobilization of the new drug on a chip surface (as the “antigen”)
appropriate control experiments to detect positive binding signals
detection of low levels of antibodies in serum samples clearly identified as a specific binding signal despite of the complexity of the protein mixture in serum samples
subtype classification of bound antibodies identifying them as IgG or IgM antibodies is possible using suitable secondary antibodies in a subsequent sandwich experiment