COMPANY PROFILE

Biaffin is a leading provider of high quality bioanalytical services and contract research specialized in biomolecular interaction analysis serving the needs of our clients from the pharmaceutical, biotechnological and diagnostic industry.

Over more than 10 years our team of Biaffin has acquired expertise and knowledge in the application of real-time biosensors based on surface plasmon resonance (SPR) to kinetically characterize any pair of interacting molecules in real-time. Fully equipped with several SPR instruments (Biacore 2000, S51, T100 / T200) we assure the performance of projects in a professional and timely manner.

Our SPR services are employed in various stages of the drug development process like fragment-based and confirmatory secondary screening, hit validation and lead optimization. Biaffin also offers kinetic characterization and validation of antibodies for diagnostic and therapeutic purposes and functional analysis of recombinant proteins and biosimilars. Besides our SPR services Biaffin offers biochemical and enzymatic assays based on microfluidic mobility shift technology (Caliper), spectrophotometric methods, bioluminescence and fluorescence polarization.

Complementary to our range of activities in interaction analysis and biochemical assays Biaffin has a broad line of products serving the customer's needs in kinase research and cellular signal transduction. Products are bioluminescence-based assays, recombinant proteins (kinases, phosphatases, cytokines), activators and inhibitors of cellular signaling pathways, peptide substrates and kinase- and phospho-specific antibodies which can be purchased from our online shop.

The Biaffin Service Team

FIELDS OF BUSINESS ACTIVITY

 

Biomolecular interaction analysis using SPR biosensors

  • Analytical services and contract research
  • Consulting and development of tailored analysis strategies
  • Kinetic validation of antibodies, biologics and biosimilars
  • Determination of active concentrations using SPR-based calibration-free methods
  • SPR based elucidation of mechanism of action to examine the driving forces of a given molecular interaction

Benefit for our customers

  • Strong expertise and knowledge in SPR technology to kinetically characterize any pair of interacting molecules in real-time
  • Sufficient capacities in Biacore instruments to perform a number of projects in parallel and to obtain results in time
  • High sensitivity for analyzing even small molecules binding to their target proteins
  • Know-how in selection and validation of antibodies based on antigen and Fc receptor binding kinetics

Selected further services

  • Biochemical and enzymatic assays based on mobility shift technology (Caliper), bioluminescence and FP

SERVICE

BIA technology is employed in various stages of the drug development process like target validation, secondary screening, hit validation and assay development. Biacore instruments are applied in functional assays, in kinetic characterisation of antibodies for diagnostic purposes as well as in quality control of recombinant proteins and in the development of biocompatible surfaces.

 

Our services include assay development for medium to high throughput binding assays and consulting for the development of novel sensor technologies with emphasis on biological applications.
We also provide screening of kinase activity by the Caliper’s mobility shift assay technology, allowing an in-depth analysis of enzyme kinetics, kinase inhibitor profiling or substrate specification.  

PRODUCTS

Biaffin´s products are recombinant proteins such as protein kinases and phosphatases, cytokines, kinase inhibitors, substrates, activators of signaling pathways, antibodies as well as bioluminescence-based assays for ATP quantification. If you are interested in our range of products please take a look at our distribution platform proteinkinase.de.

Webshop for Kinases and related products: proteinkinase.de
BIAFFIN GmbH & Co KG | Heinrich-Plett-Str. 40 | D-34132 Kassel | Germany
Tel.: +49 (0) 561-804 4661 | Fax: +49 (0) 561-804 4665 | info@biaffin.de
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